In this capital city the climate varies all year round from semi-dry, to temperate, to semi-hot, with an average annual temperature of 63°F (17°C). During the winter, an occasional morning frost can be experienced. While during spring and summer, it can be very warm, without reaching an extreme or excessive heat.

If you visit the city between the months of September and November, it is possible that you may find the afternoons rainy; while in the months form February to March, you can find the mornings cold with warm afternoons.

The changing global climate has provoked irregular and unpredictable rains throughout the entire year, where a clear and sunny day can in a few hours turn rainy, or vice-versa. For this reason, it is always recommended to be prepared for temperature changes and inclement weather.

If you visit during the rainy season (June until mid-October), comfortable walking shoes are highly recommended to navigate through the many rising and declining streets and alleyways. The rainy season generally brings rainfall about 3 or 4 times per week, with a heavy rainfall coming in around once every 10 days or so. However, don't let the rainy season discourage you, this is when Guanajuato is at its most beautiful. By August, the desert has transformed itself, and where there were only cactus and thorn bushes in April, a carpet of lush grass and wildflowers are growing.